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KMID : 1039220180280030292
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Journal of Korean Society of Occupational and Environmental Hygiene
2018 Volume.28 No. 3 p.292 ~ p.303
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Estimation of Manganese Levels in Cord Blood of Pregnant Workers
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Lee A-Ram
Choi Kyung-Ho
Kim Hai-Joong
Lee Jeong-Jae
Choi Gyu-Yeon
Kim Sung-Joo
Kim Su-Young
Cho Geum-Joon
Kim Youg-Don
Suh Eun-Sook
Kim Sung-Koo
Eun So-Hee
Eom So-Yong
Kim Seung-Hyo
Kim Gun-Ha
Moon Hyo-Bang
Kim Sung-Kyoon
Choi Soo-Ran
Park Jeong-Im
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Abstract
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Objectives: This study aims to analyze manganese (Mn) concentrations in maternal and cord bloods at delivery and to estimate the Mn exposure risk for fetuses whose mothers were occupationally exposed to Mn.
Materials and Methods: Forty-six pairs of maternal and cord blood samples were collected at delivery from mothers who were occupationally unexposed to Mn. Mn concentrations of blood were analyzed by graphite furnace atomic absorption spectrometer. Mn exposure levels for fetuses of female workers were estimated by simulating two working exposure scenarios.
Results: The geometric mean concentration of Mn in maternal and cord blood were 27.0(1.34) ㎍/L, 46.6(1.25) ㎍/L, respectively. Transfer ratios of Mn from maternal to cord blood were 1.81±0.62, which indicated that the Mn concentrations in cord blood were higher than those in maternal blood. Mn concentrations in cord blood for the worse or general scenarios were estimated to 22.3-1,881 ㎍/L and 1.59-308 ㎍/L, respectively. The probabilities of exceeding 74 ㎍/L, which was adopted as a reference level reported in a previous study, were 95% and 44% for the two scenarios, respectively.
Conclusions: Comparable levels of Mn exposure in maternal or cord blood to those in this study have shown various health effects in previous studies. This suggests that Mn exposure levels in mothers and fetuese in Korea need to be monitored and managed. In addition, female workers who are occupationally exposed to Mn should be protected from the exposure since their fetuses can be exposed to Mn at risky levels during their pregnancy.
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KEYWORD
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exposure, female workers, manganese, newborns, transfer ratio
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